The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves
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چکیده
منابع مشابه
The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves
Myelinating Schwann cells regulate the localization of ion channels on the surface of the axons they ensheath. This function depends on adhesion complexes that are positioned at specific membrane domains along the myelin unit. Here we show that the precise localization of internodal proteins depends on the expression of the cytoskeletal adapter protein 4.1G in Schwann cells. Deletion of 4.1G in...
متن کاملOrganization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B.
Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction (PNJ), whereas Caspr2 serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region (JXP). Both Caspr and Caspr2 interact with protein 4.1B, which may link the paranodal and juxtaparanodal adh...
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Three major domains can be identified in the vicinity of the node of Ranvier in myelinated nerve fibres: the node itself; the paranodal axoglial junction, where loops from the myelinating glial cell form septate junctions with the axonal plasma membrane; and the juxtaparanodal region adjacent to the paranodes (Figure 1). Over the last few years considerable advances have been made in understand...
متن کاملProtein 4.1B Contributes to the Organization of Peripheral Myelinated Axons
Neurons are characterized by extremely long axons. This exceptional cell shape is likely to depend on multiple factors including interactions between the cytoskeleton and membrane proteins. In many cell types, members of the protein 4.1 family play an important role in tethering the cortical actin-spectrin cytoskeleton to the plasma membrane. Protein 4.1B is localized in myelinated axons, enric...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2012
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201111127